Your participation in CATCH has allowed the team to look at a lot of data about people who are diagnosed with early rheumatoid arthritis and look at trends over a long period of time, to see what others like you have in common, or to see the most effective way to treat people with medications. The researchers then present these findings to other researchers at national and international scientific meetings - sometimes they give a talk and other times they will give a poster (at scientific meetings there are dedicated poster sessions where researchers really stand by posters that they've made about their research and findings at certain times and then talk to people who come by to read their posters). Researchers have to 'apply' to present their research and work at meetings, and they do that by creating an 'abstract' which is a shortened version of what they wish to present at a meeting.

All of the CATCH team research abstracts are provided here by year. Each abstract is split in to a 'short' version to give you a simple overview of the research, and if you click on the 'read more' section there is a longer version of the abstract with a few more details for you. If the CATCH team has published a scientific paper on this topic, we have also provided a link to the paper for you. We have tried to use simple language so that you can understand what the researchers did and what they found. You may wish to open our Glossary page beside the abstracts as you read them and we have also linked some more difficult terms directly to the Glossary so you can look up these words as you read (those words are shown in dark red).

If you are interested in reading the full scientific papers that have resulted from CATCH research, you can click here. The attachment provides you with information on all CATCH publications and links to the websites where they are found.

We thank you for your participation in CATCH - none of this research and none of these abstracts would be here without you.


Early Rheumatoid Arthritis (ERA) Trials have almost no Generalizability to ERA patients: Results from a Large Multi-center Cohort

The CATCH researchers wanted to see how many patients with early rheumatoid arthritis (ERA) would be eligible to participate in a clinical trial. The researchers reviewed the inclusion and exclusion criteria to be a participant in certain types of RA clinical trials. These criteria are conditions that patients have to meet in order to be in a clinical trial. This information was compared to patients in CATCH, to see how many CATCH patients would have been able to participate in those trials. About one-third of CATCH patients would not be able to be in a clinical trial because they were already taking medication to treat their RA. The researchers suggest that people planning ERA clinical trials change criteria for those clinical trials so that more patients can participate, and so that they are more reflective of the real world where patients will already be taking some medications.

Read more

What was the study purpose?
The CATCH researchers wanted to see if clinical trial data is applicable to ERA and real world patients, so they looked to see how many CATCH patients would be able to take part in clinical trials.

How was the study done?
The researchers reviewed the inclusion and exclusion criteria to participate in certain types of RA clinical trials that were publicly known. These criteria are conditions that patients must meet to be in a clinical trial. This information was compared to patients in CATCH, to see how many CATCH patients would have been eligible to be in those trials.

What were the study results?
The CATCH researchers found 44 clinical trials, and of those clinical trials, 36 were for drug treatments and 8 were to observe behavior changes. When they looked to see how many CATCH patients could have been part of those clinical trials, it ranged from between 1% to 52%. Most patients were not eligible because of some of the measures of their blood markers because they were already on medication for their RA.

This study showed a disconnect- that clinical trials are not allowing patients to participate even though those patients will likely eventually be taking those drugs. Most CATCH participants could not be in ERA clinical trials because they were already on early therapy. The CATCH researchers suggest that those people who plan trials in ERA change the criteria to be in the clinical trials so that more patients could be in them and benefit from these.